Studies on the haptoglobin of eel. IV. Binding behavior of haptoglobin with hemoglobin (2).
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Heterotropic Effect of β-lactam Antibiotics on Antioxidant Property of Haptoglobin) 2-2(-Hemoglobin Complex
Haptoglobin (Hp) is a mammalian serum glycoprotein showing a genetic polymorphism with three types, 1-1, 2-2 and 1-2. Hp appears to conserve the recycling of heme-iron by forming an essentially irreversible but non-covalent complex with hemoglobin which is released into the plasma by erythrocyte lysis. As an important consequence, Haptoglobin-Hemoglobin complex (Hp-Hb) shows considerable antiox...
متن کاملHeterotropic Effect of β-lactam Antibiotics on Antioxidant Property of Haptoglobin) 2-2(-Hemoglobin Complex
Haptoglobin (Hp) is a mammalian serum glycoprotein showing a genetic polymorphism with three types, 1-1, 2-2 and 1-2. Hp appears to conserve the recycling of heme-iron by forming an essentially irreversible but non-covalent complex with hemoglobin which is released into the plasma by erythrocyte lysis. As an important consequence, Haptoglobin-Hemoglobin complex (Hp-Hb) shows considerable antiox...
متن کاملMolecular Modeling of the Human Hemoglobin-Haptoglobin Complex Sheds Light on the Protective Mechanisms of Haptoglobin
Hemoglobin (Hb) plays a critical role in human physiological function by transporting O2. Hb is safe and inert within the confinement of the red blood cell but becomes reactive and toxic upon hemolysis. Haptoglobin (Hp) is an acute-phase serum protein that scavenges Hb and the resulting Hb-Hp complex is subjected to CD163-mediated endocytosis by macrophages. The interaction between Hb and Hp is...
متن کاملheterotropic effect of β-lactam antibiotics on antioxidant property of haptoglobin) 2-2(-hemoglobin complex
haptoglobin (hp) is a mammalian serum glycoprotein showing a genetic polymorphism with three types, 1-1, 2-2 and 1-2. hp appears to conserve the recycling of heme-iron by forming an essentially irreversible but non-covalent complex with hemoglobin which is released into the plasma by erythrocyte lysis. as an important consequence, haptoglobin-hemoglobin complex (hp-hb) shows considerable antiox...
متن کاملThe binding of hemoglobin to haptoglobin and its relation to subunit dissociation of hemoglobin.
The binding of liganded hemoglobin to haptoglobin, a plasma cr2-glycoprotein, is an irreversible and stoichiometric reaction that occurs physiologically at the micromolar concentration level. The study of the reaction between deoxyhemoglobin which does not bind haptoglobin and a haptoglobin solution saturated with carbon monoxide indicates that hemoglobin tetramer is incapable of binding haptog...
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ژورنال
عنوان ژورنال: NIPPON SUISAN GAKKAISHI
سال: 1976
ISSN: 1349-998X,0021-5392
DOI: 10.2331/suisan.42.857